A mucus secreting ready-to-use concept for intestinal absorption evaluation
CacoGoblet, a mucus-secreting ready-to-use kit. The kit consists of 24 permeable supports seeded with differentiated polarized Caco-2 and human goblet cells. It, allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithelium.
CacoGoblet is flexible, since plates can be used up to 5 days after ideal cell barrier differentation at day 21, being a time and cost-saving tool for early stage drug discovery and development.
CacoGoblet is a product manufactured in compliance with ISO 9001:2015
Evaluation of oral absorption efficiency, oral bioavailability and oral toxicity
Adaptation to High Throughput Screening of target compounds
Study of mechanisms involved in oral and intestinal absorption
Suitable for research on new delivery systems
Mucus secreting CacoGoblet represents a more predictive model for compounds or formulations with passive diffusion transport pathway
CacoGoblet allows end-users to avoid in-house maintenance and handling of cell cultures, thus reducing operating cost
The kit has been designed to provide a user-friendly and suitable tool for High Throughput automated procedures
High flexibility as the kit useable up to 5 days after 21-day cell barrier differentation
Out exclusive shipping medium ensures the stability of barrier properties
Shipping medium is easy to remove by liquefaction at 37ºC.