Hepatic drug elimination: The role of OATPs and MRP2 transporters
OATP1B1 and OATP1B3 are two influx transporters of the SLCO gene family that are primarily expressed in the sinusoidal membrane of hepatocytes.
Renal elimination of drugs: The role of kidney transporters
Understanding the role of these transporters in the clearance of new molecular entities (NME) is normally performed in-vitro at the early stages of drug development.
Cell-based in vitro models to characterize Food-Drug Interactions
It is well known that food intake changes luminal conditions (e.g. pH, motility, microbiota,…) in the stomach and the small intestine, modifying drugs bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.
Assessment of Drug Permeation across the Blood-Brain-Barrier (BBB) in preclinical research
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.
Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails
Specialized manufacturer of in vitro kits to evaluate uptake transporters, OCT2 and MATE1.
The evaluation of drug interactions in preclinical stages optimizes novel drug development
Specialized manufacturer of in vitro kits indicated to evaluate pharmacological relevant efflux and uptake receptors for TDI assays.
