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Hepatic drug elimination: The role of OATPs and MRP2 transporters

Hepatic drug elimination: The role of OATPs and MRP2 transporters

Jul 27, 2022

OATP1B1 and OATP1B3 are two influx transporters of the SLCO gene family that are primarily expressed in the sinusoidal membrane of hepatocytes.

Renal elimination of drugs: The role of kidney transporters

Renal elimination of drugs: The role of kidney transporters

Jun 28, 2022

Understanding the role of these transporters in the clearance of new molecular entities (NME) is normally performed in-vitro at the early stages of drug development.

Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails

Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails

Oct 26, 2021

Specialized manufacturer of in vitro kits to evaluate uptake transporters, OCT2 and MATE1.

The evaluation of drug interactions in preclinical stages optimizes novel drug development

The evaluation of drug interactions in preclinical stages optimizes novel drug development

Sep 30, 2021

Specialized manufacturer of in vitro kits indicated to evaluate pharmacological relevant efflux and uptake receptors for TDI assays.

PreadyTake MATE1, Screening Renal and Hepatic Drug Metabolism

PreadyTake MATE1, Screening Renal and Hepatic Drug Metabolism

Jun 29, 2020

In vitro systems based on HEK293 cells are a recommended technique to assess MATE1 transporter interactions during preclinical stages.

Categories

CORPORATE (11) CYTOTOXICITY (1) EFFLUX TRANSPORTERS (10) EVENTS (16) PARTNERSHIP (11) PERMEABILITY (11) REGULATORY (2) RESEARCH (11) TRANSPORTER DRUG INTERACTION (13) UPTAKE RECEPTORS (5)

Tags

BCRP (8) BLOOD-BRAIN BARRIER (3) CACO2 (14) CELL PRESERVATION (3) CELL SHIPMENTS (2) CYTOTOXICITY (1) EFFLUX TRANSPORT (9) EVENT (22) HEK293 (3) MATE 1 (5) MDCK CELLS (8) MDR1 (2) OCT2 (3) P-GP (9) PERMEABILITY (10) ROOM TEMPERATURE TRANSPORTATION (5) SHIPPING (1) TOXICITY (1) UPTAKE TRANSPORT (7)
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