Transporter Drug Interaction

Efflux Transporters

Optimize the need for and proper design of potential future clinical studies with our range of ready-to-use efflux transporter kits.

BCRP efflux evaluation for early assessment of drug candidates

24 or 96 transwell insert plates with differentiated MDCK II cells expressing BCRP as well as the parental cell line. BCRP (breast cancer resistance protein; ABCG2) is a high-capacity efflux transporter with broad substrate specificity recognizing large, hydrophobic molecules of either negative or positive charge, organic anions, and sulfate conjugates.

Identify P-gp mediated active efflux

24 or 96 transwell insert plates with differentiated MDCK II cells expressing MDR1 as well as the parental cell line. P-gp not only has a critical role in limiting the entry of drugs into the central nervous system but also plays a part in the intestinal absorption and in the biliary and urinary excretion of drugs.

  Screening kit for hepatic metabolism based on transfected MDCK II cells

24 transwell insert plates with differentiated MDCK II cells expressing MRP2 as well as the parental cell line. MRP2 receptor is highly expressed in the liver, showing a relevant role in bilirubin conjugated metabolites. Regulatory agencies are considering receptor relevance in terms of pharmacokinetic activity

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REFERENCE DESCRIPTION
KRECE-CTR02 PreadyPort-CTRL (24 Transwell)
KRECE-MRP01 PreadyPort-MRP2 (24 Transwell)
KRECE-MRP02 PreadyPort-MRP2/CTRL 1:1 (24 Transwell)

ReadyCell ready-to-use cell monolayer kits benefits

 

  • No in-house cell culture maintenance nor cell licensing costs
  • Shipments worldwide to any location at room temperature thanks to our patented technology
  • High flexibility
  • High reproducibility within and between manufacturing batches
  • Cell-based assays ready-to-use
  • Full cell functionality after transportation
  • Highly predictive and useful in the in vitro to in vivo progression
  • Validation data available and high quality-control standards
  • Technical support during the assay and in bio-analytics