CacoReady in the literature

16 December 2021
Communications Department

Our partners from University of Messina have published “Antioxidant and Anti-Inflammatory Activity of Citrus Flavanones Mix and Its Stability after In Vitro Simulated Digestion” in the international Antioxidants journal.

The study assesses the anti-inflammatory activity of Citrus Flavonoves with Caco-2 cells based model stimulated with interleukins.

About the study

Citrus Flavanones are considered as antioxidant metabolites, as well as free radical and antiinflamatory agents. Specifically, it has been proven that they can be multi-target agents against chronic disorders such as the inflammatory bowel disease (IBD).

Currently, there is no resolutive pharmacological treatment, since the therapies are focused on non-specific immunosuppressive drugs.

The aim of the study was to select the most representative flavanones of the Citrus genus by performing an in vitro antioxidant and anti-inflammatory screening and mix the most promising ones in equimolar ratio to obtain a flavanones mix (FM). Finally, they evaluated the availability of the FM and its anti-inflammatory effects at the intestinal level, using our CacoReady kit stimulated with interleukin (IL)-1β, a well-known pro-inflammatory agent.


The study detected the most powerful antioxidant and anti-inflammatory compounds among the investigated Citrus flavanones, and that the particular structural features of these molecules make them available at the intestinal level, where they can exert their remarkable anti-inflammatory activities.
Moreover, they demonstrated that the flavanones mix exerts already at a pharma-nutritional dose, an anti-inflammatory activity comparable or higher with respect to the reference drugs.

Read article: Antioxidant and Anti-Inflammatory Activity of Citrus Flavanones Mix and Its Stability after In Vitro Simulated Digestion

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