MPS-LOC: Microphysiological systems based on liver on chip for drug discovery and testing

Team of the liver on chip project
ReadyCell Communications Department
18 April 2023

ReadyCell is partaking in a new collaborative project together with Leitat Technological Center and Vall d’Hebron Institute of Research (VHIR). MPS-LOC has been awarded by the competitive grant “Proyectos de I+D+i en Líneas Estratégicas 2022” from the Spanish Ministry of Science and Innovation (Ministerio de Ciencia e Innovación) through its funding agency Agencia Estatal de Investigación (AEI).”

The project aims to develop microphysiological systems based on liver-on-chip for drug discovery and testing. By utilizing systems that converge microfluidics, 3D printing, human-derived liver cells and liver derived bioinks, the MPS-LOC project seeks to substitute the use of animal models and provide high predictive value in preclinical drug development.

Leading partners of the project

To ensure success, the project consortium has brought together leading partners with diverse expertise.

The Coordination of Donation and Transplant Programmes Team as well as both the Paediatric Hepatic Transplant Unit, and the Hepatobiliary and Pancreatic Surgery and Transplant Department from Vall d’Hebron University Hospital, and their respective research groups (Donation and transplantation of organs, tissues and cells and Hepato-bilio-pancreatic surgery and liver transplantation) from Vall d’Hebron Institute of Research (VHIR) – Vall d’Hebron Institut de Recerca will coordinate and obtain liver tissue from the organs donated and discarded for transplantation.

The Leitat Medical Department of Leitat Technological Center will be responsible for isolating liver cells, obtaining liver-derived substrates and generating bioinks. Subsequently, the Diagnostic Devices Group of Leitat will design and manufacture the liver-on-chip device and optimize its microfluidic dynamics.

Finally, ReadyCell S.L., as the industry partner, will lead the validation of the liver-on-chip devices in order to obtain the final ready-to-use liver-on-chip product.

Last March, representatives from the three partners held the Kick-off meeting of the project.

ReadyCell is involved in several research projects with public and private organizations and is always keen to examine new scientific collaborations. Find here all ReadyCell collaborative projects.

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