Permeability Assays
Ready-to-use drug permeability kits will help you to ascertain your compound suitability for oral dosing.
Studying the permeability of compounds across a cell monolayer is a well-established in vitro technique to screen for oral absorption and evaluate transport mechanisms. Our range of pre-plated transwell products allows the rapid and accurate determination of drug transport across Caco-2 and MDCK II cell monolayers.
Your one-stop Caco-2 solution
24 or 96 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 cells. The reference in vitro technique to evaluate intestinal permeability in novel orally administered compounds, according to leading regulatory agencies.
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| REFERENCE | DESCRIPTION | |
| KRECE-CCR01 | CacoReady 24 Transwell | |
| KRECE-CCR02 | CacoReady 24 Well (without transwell) | |
| KRECE-CCR04 | CacoReady 24 Well (individual transwell) | |
| KRECE-CCR50 | CacoReady 96 Transwell | |
| KRECE-CCR51 | CacoReady 96 Well (without transwell) |
CacoReady in the Literature
A secreting mucus intestinal barrier
24 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 and HT-29 (human goblet) cells. An in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithelium.
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| REFERENCE | DESCRIPTION | |
| KRECE-CCG01 | CacoGoblet 24 Transwell | |
| KRECE-CCG02 | CacoGoblet 24 (individual transwell) |
CacoGoblet in the literature
An alternative cellular model based on MDCKII cells
24 and 96 transwell insert plates cultured with 12 days differentiated MDCKII parental line cells. A reference in vitro model to evaluate passive permeation and specific receptor mediated transport of new compounds.
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| REFERENCE | DESCRIPTION | |
| KRECE-CTR01 | PreadyPort-CTRL (24 Transwell) | |
| KRECE-CTR50 | PreadyPort-CTRL (96 Transwell) | |
| KRECE-MDR01 | PreadyPort-MDR1 (24 Transwell) | |
| KRECE-MDR02 | PreadyPort-MDR1/CTRL 1:1 (24 Transwell) | |
| KRECE-MDR50 | PreadyPort-MDR1 (96 Transwell) | |
| KRECE-MDR51 | PreadyPort-MDR1/CTRL 1:1 (96 Transwell) |
PreadyPort in the literature
ReadyCell ready-to-use cell monolayer kits benefits
- No in-house cell culture maintenance nor cell licensing costs
- Shipments worldwide to any location at room temperature thanks to our patented technology
- High flexibility
- High reproducibility within and between manufacturing batches
- Cell-based assays ready-to-use
- Highly predictive and useful in the in vitro to in vivo progression
- Technical support during the assay and in bio-analytics
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Caco-2 based in vitro models for the screening of anti-inflammatory drugs
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Cell-based in vitro models to characterize Food-Drug Interactions
It is well known that food intake changes luminal conditions (e.g. pH, motility, microbiota,…) in the stomach and the small intestine, modifying drugs bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.
Assessment of Drug Permeation across the Blood-Brain-Barrier (BBB) in preclinical research
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.