CacoReady is an innovative cell-based and ready-to-use kit. The kit consists of 24 and 96 insert-integrated permeable support seeded with differentiated and polarized Caco-2 barriers on polycarbonate microporous filters. CacoReady allows in vitro intestinal absorption evaluation of drug targets. CacoReady is flexible since plates can be used up to 5 days after ideal cell barrier differentiation at day 21. CacoReady is a time and cost-saving tool for early stage drug discovery and development.
Monolayer assays using transfected MDCKII-BRCP cells have been widely recognized tools to study the interaction of drugs with the BCRP transporter. This system is suitable for performing both inhibition and substrate assessments. MDCKII-BCRP is used to model the net transport events of important fluid compartment barriers in the organism that express BCRP at high level. BCRP transporter is present in the blood-brain-barrier, intestine, liver, kidney, testis and mammary tissue.
PreadyPort-MDR1 kits contains 24-insert integrated plates with differentiated MDCKII cells expressing MDR1, as well as the parental cell line. The first member of the PreadyPort™ series, the PreadyPort-MDR1 kit is revolutionary in providing a ready-to-use tool for MDCKII-MDR1 monolayer assays. The kit will allow researchers to perform MDR1 interaction studies on monolayers without bothering about cell-line licensing and culturing.
CacoGoblet is a mucus-secreting ready-to-use kit. The kit contains differentiated polarized Caco-2 and human goblet cells seeded on polycarbonate microporus filters. CacoGoblet allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithelium. CacoGoblet is a target system for hydrophilic compounds.
Main customer’s presence around the world:
Approximate delivery times: