CacoReady™ is an innovative cell-based and ready-to-use kit. The kit consists of 24 and 96 insert-integrated permeable support seeded with differentiated and polarized Caco-2 barriers on polycarbonate microporous filters. CacoReady™ allows in vitro intestinal absorption evaluation of drug targets. CacoReady™ is flexible since plates can be used up to 5 days after ideal cell barrier differentiation at day 21. CacoReady™ is a time and cost-saving tool for early stage drug discovery and development.
Monolayer assays using transfected MDCKII-BRCP (ABCG2) cells have been widely recognized tools, acknowledged by the ITC1 , to study the interaction of drugs with the BCRP transporter. This system is suitable for performing both inhibition and substrate assessments. MDCKII-BCRP is often used to model the net transport events of important fluid compartment barriers in the organism that express BCRP at high level. BCRP transporter is present in the blood-brain-barrier, intestine, liver, kidney, testis and mammary tissue.
PreadyPort™-MDR1 kits contains 24-insert integrated plates with differentiated MDCKII cells expressing MDR1, as well as the parental cell line. The first member of the PreadyPort™ series, the PreadyPort™-MDR1 kit is revolutionary in providing a ready-to-use tool for MDCKII-MDR1 monolayer assays. The kit will allow researchers to perform MDR1 interaction studies on monolayers without bothering about cell-line licensing and culturing.
CacoGoblet, is a mucus-secreting ready-to-use kit. The kit contains differentiated polarized Caco-2 and human goblet cells seeded on polycarbonate microporus filters. CacoGoblet allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithelium. CacoGoblet is a target system for hydrophilic compounds.
Approximate delivery times: USA and Canada: 48h – Europe: 24h – Asia: between 48-72h