Kits to facilitate the development and testing of new drugs

Our kits help you in your drug discovery and development studies. They are stored and transported at room temperature, are available on demand and facilitate your drug discovery and development studies assays.

Caco-2 based Ready-to-Use permeability models

CacoReady™ is an innovative cell-based and ready-to-use kit. The kit consists of 24 and 96 insert-integrated permeable support seeded with differentiated and polarized Caco-2 barriers on polycarbonate microporous filters. CacoReady™ allows in vitro intestinal absorption evaluation of drug targets. CacoReady™ is flexible since plates can be used up to 5 days after ideal cell barrier differentiation at day 21. CacoReady™ is a time and cost-saving tool for early stage drug discovery and development.

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Study the interaction of drugs with the BCRP transporter

Monolayer assays using transfected MDCKII-BRCP (ABCG2) cells have been widely recognized tools, acknowledged by the ITC1 , to study the interaction of drugs with the BCRP transporter. This system is suitable for performing both inhibition and substrate assessments. MDCKII-BCRP is often used to model the net transport events of important fluid compartment barriers in the organism that express BCRP at high level. BCRP transporter is present in the blood-brain-barrier, intestine, liver, kidney, testis and mammary tissue.

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Model the net transport events of fluid compartment barrriers

PreadyPort™-MDR1 kits contains 24-insert integrated plates with differentiated MDCKII cells expressing MDR1, as well as the parental cell line. The first member of the PreadyPort™ series, the PreadyPort™-MDR1 kit is revolutionary in providing a ready-to-use tool for MDCKII-MDR1 monolayer assays. The kit will allow researchers to perform MDR1 interaction studies on monolayers without bothering about cell-line licensing and culturing.

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A Mucus Secretomg Ready-to-use Concept for in vitro Intestinal Absorption Evaluation

CacoGoblet, is a mucus-secreting ready-to-use kit. The kit contains differentiated polarized Caco-2 and human goblet cells seeded on polycarbonate microporus filters. CacoGoblet allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithelium. CacoGoblet is a target system for hydrophilic compounds.

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Benefits

  • Time and cost saving (Reduction of in-house cell culture maintenance, avoiding variability due to cell culture and/or no cell licensing cost)
  • Cell-based Assays, Ready-to-Use
  • Shipments worldwide to any location at room temperature thanks to our technology “Shipping Medium” avoiding using dry ice or liquid nitrogen.
  • High flexibility (Stable up to 5 days after cell barrier differentiation)
  • Highly predictive and useful in the in vitro to in vivo progression
  • High reproducibility within and between manufacturing batches
  • Full cell functionality after transportation
  • Validation data available and high quality-control standards
  • Technical support during the assay and in bio-analytics

Shipping Medium:

 

 

ReadyCell’s patented shipping technology

  • An innovative gel-like cell preservation matrix
  • Allows preservation of cells in a non-frozen state with minimal loss of viability and functional integrity
  • Extend cells’ period of usability
  • Recover rapidly cells from the matrix and use them as freshly isolated cells
  • Remains in optimal conditions at RT 15-25⁰C and starts to liquefy at 37⁰C
  • Preserves integrity and cell junctions for 5 days during storage and transportation
  • All components of the system are non-toxic

Approximate delivery times: USA and Canada: 48h – Europe: 24h – Asia: between 48-72h