READY-TO-USE KITS

ReadyCell Products

Our cell-based kits maximize efficacy and safety testing of new molecular entities during preclinical drug discovery and development.

Worldwide shipments to any location at room temperature thanks to our technology.

Products conceived according to main regulatory agencies’ requirements.

Free consultation and technical support during the assay and in bio-analytics.

READY-TO-USE MODELS

Available Kits

ReadyCell solutions

Caco-2 cell Kits

Your one-step Caco-2 solution

24 or 96 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 cells. This cell model is considered to be the gold standard for assessing intestinal permeability of new oral drugs in in vitro preclinical studies, according to leading regulatory agencies.

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CATALOG #: DESCRIPTION

  • KRECE-CCR01: CacoReady 24 Transwell
  • KRECE-CCR02: CacoReady 24 Well (without transwell)
  • KRECE-CCR04: CacoReady 24 Well (individual transwell)
  • KRECE-CCR50: CacoReady 96 Transwell
  • KRECE-CCR51: CacoReady 96 Well (without transwell)

 

  • Drug permeability by passive diffusion and/or active transport through a physiologically relevant barrier.
  • Relevant barrier for the active transport of drugs through the Blood Brain Barrier.
  • Carrier-mediated transport mechanisms.
  • Drug toxicity.

A secreting mucus intestinal barrier

24 transwell insert plates seeded with 21 days differentiated and polarized Caco-2 and HT-29 cells with an absorptive and mucus-secreting phenotype, respectively. This co-culture allows evaluating the in vitro intestinal absorption of drug targets at a barrier physiologically closer to the intestinal epithelium. In addition, their responsiveness to inflammatory mediators provides valuable information on the efficacy of anti-inflammatory drugs.

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CATALOG #: DESCRIPTION

  • KRECE-CCG01: CacoGoblet 24 Transwell
  • KRECE-CCG02: CacoGoblet 24 Well (individual transwell)
  • Drug permeability by passive diffusion and/or active transport through a physiologically relevant barrier.
  • Carrier-mediated transport mechanisms.
  • Drug toxicity.
  • Anti-inflammatory drug testing.

ReadyCell solutions

MDCKII cell Kits

A relevant barrier for passive diffusion

24 and 96 transwell insert plates cultured with the 12 days differentiated MDCKII parental cell line. A reference in vitro model to evaluate passive permeation of orally administered drugs.

Download brochure PreadyPort WT 24
Download brochure PreadyPort WT 96

CATALOG #DESCRIPTION

  • KRECE-CTR01: PreadyPort-CTRL (24 Transwell)
  • KRECE-CTR50: PreadyPort-CTRL (96 Transwell)
  • Assaying drug permeability by passive diffusion
    through a physiologically relevant barrier.
  • Drug permeability by passive diffusion through the Blood Brain Barrier.
  • Negative control for PreadyPort Kits overexpressing the MDR1
    and/or BCRP efflux transporter.

P-gp, an efflux transporter pump

24 or 96 transwell insert plates cultured with 12 days differentiated MDR1-overexpressing MDCKII cells. The MDR1 efflux transporter has an ubiquitous tissue distribution, with a critical role in intestinal absorption, biliary and urinary excretion of drugs and in the entry of active molecules into the central nervous system.

Download brochure PreadyPort MDR1 24
Download brochure PreadyPort MDR1 96

CATALOG #DESCRIPTION

  • KRECE-CTR01: PreadyPort-CTRL (24 Transwell)
  • KRECE-CTR50: PreadyPort-CTRL (96 Transwell)
  • KRECE-MDR01: PreadyPort-MDR1 (24 Transwell)
  • KRECE-MDR02: PreadyPort-MDR1/CTRL 1:1 (24 Transwell)
  • KRECE-MDR50: PreadyPort-MDR1 (96 Transwell)
  • KRECE-MDR51: PreadyPort-MDR1/CTRL 1:1 (96 Transwell)
  • MDR1 substrates, inhibitors and inducers.
  • MDR1 transporter-based drug-drug interactions (concomitantly administered drugs).
  • Drug permeability by passive diffusion through a physiologically relevant barrier.
  • Drug permeability by passive diffusion and MDR1 transporter through the Blood Brain Barrier.

BCRP, an ATP-binding cassette (ABC) transporter protein

24 or 96 transwell insert plates cultured with 12 days differentiated BCRP-overexpressing MDCKII cells. BCRP is a high-capacity efflux transporter with broad substrate specificity. It is located in the apical cell membrane of barrier tissues and and excretory organs.

Download brochure PreadyPort BCRP 24
Download brochure PreadyPort BCRP 96

CATALOG #DESCRIPTION

  • KRECE-CTR01: PreadyPort-CTRL (24 Transwell)
  • KRECE-CTR50: PreadyPort-CTRL (96 Transwell)
  • KRECE-BCP01: PreadyPort-BCRP(24 Transwell)
  • KRECE-BCP02: PreadyPort-BCRP/CTRL 1:1 (24 Transwell)
  • KRECE-BCP50: PreadyPort-BCRP(96 Transwell)
  • KRECE-BCP51: PreadyPort-BCRP/CTRL 1:1 (96 Transwell)
  • BCRP substrates, inhibitors and inducers.
  • BCRP transporter-based drug-drug interactions (concomitantly administered drugs).
  • Drug permeability by passive diffusion through a physiologically relevant barrier.

CUSTOM MADE PLATES

Set up your PreadyPort and PreadyTake plates with several clones cultures

Customize your 24-well and 96-well plates by combining MDCKII cells or HEK293 cells overexpressing efflux and uptake transporters respectively, according to the assay requirements.

ReadyCell solutions

HEK293 cell Kits

A key transporter for renal and biliary excretion

96 multiwell insert plates with differentiated MATE1-overexpressing HEK293 cells. Drug-transporter interactions involving MATE1 may compromise drug renal clearance and biliary excretion.

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CATALOG #DESCRIPTION

  • KRECE-HEK50: PreadyTake-CTRL (96 Multiwell)
  • KRECE-MAT50: PreadyTake-MATE1 (96 Multiwell)
  • KRECE-MAT51: PreadyTake-MATE1/CTRL 1:1 (96 Multiwell)
  • MATE1 substrates, inhibitors and inducers.
  • MATE1 transporter-based drug-drug interactions (concomitantly administered drugs).
  • Competitive inhibition (unexpected drug elimination).

OCT2 for renal clearance

96 multiwell insert plates with differentiated OCT2-overexpressing HEK293 cells. The OCT2 transporter carries a wide range of different solutes across biological membranes being especially relevant for those drugs that are renally excreted.

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CATALOG #DESCRIPTION

  • KRECE-HEK50: PreadyTake-CTRL (96 Multiwell)
  • KRECE-OCT50: PreadyTake-OCT2 (96 Multiwell)
  • KRECE-OCT51: PreadyTake-OCT2/CTRL 1:1 (96 Multiwell)
  • OCT2 substrates, inhibitors and inducers.
  • Compound interactions (concomitantly administered drugs).
  • Competitive inhibition (unexpected drug elimination).

ReadyCell solutions

Supplementary Reagents

At ReadyCell we provide all necessary and appropriate solutions for each assay to efficiently ease your screening.

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