PREADYPORT FAMILY
PREADYPORT FAMILY
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MDCKII BASED MODELS OF ACTIVE TRANSPORT IN READY-TO-USE FORMAT

MDCKII cells are often transfected with transporter proteins to investigate drug efflux and/or uptake. Therefore, this cell line is a useful model for the identification of different transporter substrates and inhibitors

MDCKII based models of active transport in ready-to-use format

As MDCKII cells endogenously express other transporters such as canine P-gp3, it is recommended that the compound is screened through the MDCK (Wild Type) Permeability assay to calculate a net flux ratio in order to confirm the role of human P-gp in the MDR1-MDCK studies.

PreadyPort family include different types of approaches to transporter studies, including FDA and EMA recommended models besides new and exclusive approaches to better understand drug transport:

FACTS

  • Madin Darby canine kidney (MDCK) cells are an epithelial cell line of canine kidney origin.
  • MDCKII cells have low expression of transporter proteins and low metabolic activity.
  • MDCKII cells are often transfected with transporter proteins to investigate drug efflux and/or uptake.

BENEFITS

  • Available on demand.
  • Ready-to-use.
  • User-friendly and easy-handling system.
  • Adaptable to automation.
  • Transporter experiments without in-house cell propagation.
  • Transporter experiments without in-house cell line development, or acquisition.
PReadyPort

Drug-Drug interaction.

Single transporter overexpression to specifically dissect substrate or inhibitor intections.

Efflux Transporters

MDCK II Based EFFLUX Transporter Kits

Specific Clearance

Tandem transporter set up to study active net transport

PreadyPort MDR1 Predyctive-MRP2 kits

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