Assessment of Drug Permeation across the Blood-Brain-Barrier (BBB) in preclinical research
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS)...
The evaluation of drug interactions in preclinical stages optimizes novel drug development
Drug-drug interactions (DDI) are an important risk factor for polymedicated patients, as they can compromise safety and alter the efficacy of medical treatments. These interactions are usually related to drugs, however, they have also been identified between...
Role of pharmacological efflux receptors in cancer treatment resistance
Clinical evidence revealed that multi-drug resistance (MDR) is one of the major pharmacological challenges to obtain the required cytotoxic effect in tumoral cells compared to their healthy counterparts. Resistance of cancer cells against chemotherapeutics may occur...