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The evaluation of drug interactions in preclinical stages optimizes novel drug development

The evaluation of drug interactions in preclinical stages optimizes novel drug development

Sep 30, 2021

Drug-drug interactions (DDI) are an important risk factor for polymedicated patients, as they can compromise safety and alter the efficacy of medical treatments. These interactions are usually related to drugs, however, they have also been identified between...
Role of pharmacological efflux receptors in cancer treatment resistance

Role of pharmacological efflux receptors in cancer treatment resistance

Jul 19, 2021

Clinical evidence revealed that multi-drug resistance (MDR) is one of the major pharmacological challenges to obtain the required cytotoxic effect in tumoral cells compared to their healthy counterparts. Resistance of cancer cells against chemotherapeutics may occur...
Recommended cell-based in vitro testing to assess BCRP protein-mediated transport

Recommended cell-based in vitro testing to assess BCRP protein-mediated transport

Jun 3, 2021

Efflux transporters are membrane proteins often involved in poor absorption and low oral bioavailability of drugs as those are kept out of the cells and effluxed back into the intestinal lumen. With this in mind, prediction of drug-transporter interactions during drug...

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BCRP (3) BLOOD-BRAIN BARRIER (2) CACO2 (4) CELL PRESERVATION (1) CELL SHIPMENTS (1) EFFLUX TRANSPORT (4) EFFLUX TRANSPORTER (1) EVENT (1) HEK293 (3) MATE 1 (4) MDCK CELLS (4) MDR1 (2) OCT2 (3) P-GP (3) PERMEABILITY (5) ROOM TEMPERATURE TRANSPORTATION (1) SHIPPING (1) TOXICITY (1) UPTAKE TRANSPORT (4)
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