Recommended cell-based in vitro testing to assess BCRP protein-mediated transport
Efflux transporters are membrane proteins often involved in poor absorption and low oral bioavailability of drugs as those are kept out of the cells and effluxed back into the intestinal lumen. With this in mind, prediction of drug-transporter interactions during drug...
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?
The pharmacological implications in blood-brain barrier permeability assays. Drug delivery to the brain is a challenging evaluation to consider during novel compounds discovery stages to study central nervous pharmacokinetics in terms of efficacy and safety. This is...