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The evaluation of drug interactions in preclinical stages optimizes novel drug development

The evaluation of drug interactions in preclinical stages optimizes novel drug development

Sep 30, 2021

Drug-drug interactions (DDI) are an important risk factor for polymedicated patients, as they can compromise safety and alter the efficacy of medical treatments. These interactions are usually related to drugs, however, they have also been identified between...
MDCK II cells overexpressing MDR1 protein. A must assay for drug development.

MDCK II cells overexpressing MDR1 protein. A must assay for drug development.

Jan 29, 2021

The multidrug resistance protein 1, MDR1 is an efflux transporter that plays an important role in pharmacokinetic activity. This transmembranal transporter regulates the absorption, excretion, and distribution of xenobiotic compounds from the body. MDR1, also known as...

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BCRP (5) BLOOD-BRAIN BARRIER (3) c (1) CACO2 (7) CELL PRESERVATION (2) CELL SHIPMENTS (2) EFFLUX TRANSPORT (5) EFFLUX TRANSPORTER (1) EVENT (1) HEK293 (3) MATE 1 (4) MDCK CELLS (6) MDR1 (2) OCT2 (3) P-GP (5) PERMEABILITY (6) research (1) ROOM TEMPERATURE TRANSPORTATION (2) SHIPPING (1) TOXICITY (1) UPTAKE TRANSPORT (4)
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