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Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails

Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails

Oct 26, 2021

Drug-drug interactions are the most common cause of adverse events during clinical stages in polymedicated patients. Alterations in drugs’ metabolism due to unexpected molecular interactions affect significantly compounds’ pharmacokinetics. The scientific community...
The evaluation of drug interactions in preclinical stages optimizes novel drug development

The evaluation of drug interactions in preclinical stages optimizes novel drug development

Sep 30, 2021

Drug-drug interactions (DDI) are an important risk factor for polymedicated patients, as they can compromise safety and alter the efficacy of medical treatments. These interactions are usually related to drugs, however, they have also been identified between...
The latest #FDA guidance on in vitro drug-drug interactions is finally out!

The latest #FDA guidance on in vitro drug-drug interactions is finally out!

Feb 28, 2020

Among other things, the agency explains that DDIs are a critical factor in a drug’s overall benefit-risk profile. The results of in vitro #DDI studies and pharmacokinetic (PK) data “provide mechanistic information that can inform the need for and proper design of...

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  • The evaluation of drug interactions in preclinical stages optimizes novel drug development

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