Cell-based in vitro models to characterize Food-Drug Interactions

Pharmacokinetics (PK) studies the movement of drugs into, through, and out of the body, which is of utmost importance to ensure their safety and efficacy. Food-effects, drug-drug interaction, drug-disease interactions, or use in a special population can modify this...
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?

Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?

The pharmacological implications in blood-brain barrier permeability assays. Drug delivery to the brain is a challenging evaluation to consider during novel compounds discovery stages to study central nervous pharmacokinetics in terms of efficacy and safety. This is...