Assessment of Drug Permeation across the Blood-Brain-Barrier (BBB) in preclinical research
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS)...
Role of pharmacological efflux receptors in cancer treatment resistance
Clinical evidence revealed that multi-drug resistance (MDR) is one of the major pharmacological challenges to obtain the required cytotoxic effect in tumoral cells compared to their healthy counterparts. Resistance of cancer cells against chemotherapeutics may occur...
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?
The pharmacological implications in blood-brain barrier permeability assays. Drug delivery to the brain is a challenging evaluation to consider during novel compounds discovery stages to study central nervous pharmacokinetics in terms of efficacy and safety. This is...