Cancer drug development: what to know about ABC transporters

Cancer drug development: what to know about ABC transporters

The presence of the superfamily members of the ATP binding cassette (ABC) transporters is well established as the main cause of multidrug resistance, since they efflux therapeutic compounds from cells and reduce the intracellular drug levels.

New hyperoxia drug study references CacoReady Kits

New hyperoxia drug study references CacoReady Kits

The publication, entitled Daily Intraperitoneal Administration of RGZ Does Not Improve Lung Function or Alveolarization in Preterm Rabbits Exposed to Hyperoxia, was aimed at testing the efficacy of three types of Thiazolidenoides (TZN) in preterm rabbits with bronchopulmonary dysplasia.

Cell-based in vitro models to characterize Food-Drug Interactions

Cell-based in vitro models to characterize Food-Drug Interactions

It is well known that food intake changes luminal conditions (e.g. pH, motility, microbiota,…) in the stomach and the small intestine, modifying drugs bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.