MDCK II cells overexpressing MDR1 protein. A must assay for drug development.

MDCK II cells overexpressing MDR1 protein. A must assay for drug development.

The multidrug resistance protein 1, MDR1 is an efflux transporter that plays an important role in pharmacokinetic activity. This transmembranal transporter regulates the absorption, excretion, and distribution of xenobiotic compounds…

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Caco-2 Permeability Assay Protocol

Caco-2 Permeability Assay Protocol

Culturing Caco-2 cells in Transwell plates is considered the reference in vitro technique to evaluate intestinal permeability in novel orally administered compounds, according to leading regulatory agencies (FDA, EMA and…

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