Cell-based in vitro models to characterize Food-Drug Interactions

Pharmacokinetics (PK) studies the movement of drugs into, through, and out of the body, which is of utmost importance to ensure their safety and efficacy. Food-effects, drug-drug interaction, drug-disease interactions, or use in a special population can modify this...
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?

Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?

The pharmacological implications in blood-brain barrier permeability assays. Drug delivery to the brain is a challenging evaluation to consider during novel compounds discovery stages to study central nervous pharmacokinetics in terms of efficacy and safety. This is...
Caco-2 Permeability Assay Protocol

Caco-2 Permeability Assay Protocol

Culturing Caco-2 cells in Transwell plates is considered the reference in vitro technique to evaluate intestinal permeability in novel orally administered compounds, according to leading regulatory agencies (FDA, EMA and PMDA). The primary outcome of such technique is...