Review of available cell-based in vitro models to evaluate intestinal permeability
In vitro models are commonly used and wildly accepted in research stages that investigate several biological processes, reducing animal experimentation, simplifying discovery projects, and minimizing operational costs. The gastrointestinal (GI) system is considered a...
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?
The pharmacological implications in blood-brain barrier permeability assays. Drug delivery to the brain is a challenging evaluation to consider during novel compounds discovery stages to study central nervous pharmacokinetics in terms of efficacy and safety. This is...
MDCK II cells overexpressing MDR1 protein. A must assay for drug development.
The multidrug resistance protein 1, MDR1 is an efflux transporter that plays an important role in pharmacokinetic activity. This transmembranal transporter regulates the absorption, excretion, and distribution of xenobiotic compounds from the body. MDR1, also known as...