Drug-Drug Interactions
Uptake Transporters
Optimize the need for and proper design of potential future clinical studies with our range of ready-to-use uptake transporter kits.
DDI screening represents a necessary means not only for assessing and ranking potential drug candidates but also for aiding in the development of mechanisms for predicting and retrospectively explaining in vitro drug performance. Our pre-plated overexpressed transporters allow the study of clinically relevant ligand-receptor interaction effects.
A key transporter for the secretion of organic cations
96 multiwell insert plates with differentiated HEK 293 cells expressing MATE1 as well as the parental cell line. Drug-drug interactions involving MATE1 may result in decreased renal clearance and a corresponding increase in exposure, hence its importance when the development drug’s renal active secretion is significant.
More info...
| REFERENCE | DESCRIPTION | |
| KRECE-HEK50 | PreadyTake-CTRL (96 Multiwell) | |
| KRECE-MAT50 | PreadyTake-MATE1 (96 Multiwell) | |
| KRECE-MAT51 | PreadyTake-MATE1/CTRL 1:1 (96 Multiwell) |
Investigate the renal clearance of drug substrates
96 multiwell insert plates with differentiated HEK 293 cells expressing OCT2 as well as the parental cell line. The SLC (solute carrier) family transport a wide range of different solutes across biological membranes using diverse energy coupling mechanisms; OCT2 becomes critical when the development drug’s renal active secretion is significant.
More info...
| REFERENCE | DESCRIPTION |
| KRECE-HEK50 | PreadyTake-CTRL (96 Multiwell) |
| KRECE-OCT50 | PreadyTake-OCT2 (96 Multiwell) |
| KRECE-OCT51 | PreadyTake-OCT2/CTRL 1:1 (96 Multiwell) |
ReadyCell ready-to-use cell monolayer kits benefits
- No in-house cell culture maintenance nor cell licensing costs
- Shipments worldwide to any location at room temperature thanks to our patented technology
- High flexibility
- High reproducibility within and between manufacturing batches
- Cell-based assays ready-to-use
- Full cell functionality after transportation
- Highly predictive and useful in the in vitro to in vivo progression
- Validation data available and high quality-control standards
- Technical support during the assay and in bio-analytics
Related News
Renal elimination of drugs: The role of kidney transporters
Understanding the role of these transporters in the clearance of new molecular entities (NME) is normally performed in-vitro at the early stages of drug development.
Cell-based in vitro models to characterize Food-Drug Interactions
It is well known that food intake changes luminal conditions (e.g. pH, motility, microbiota,…) in the stomach and the small intestine, modifying drugs bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.
Assessment of Drug Permeation across the Blood-Brain-Barrier (BBB) in preclinical research
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.