Drug-Drug Interactions

Uptake Transporters

Optimize the need for and proper design of potential future clinical studies with our range of ready-to-use uptake transporter kits.

  A key transporter for the secretion of organic cations

96 multiwell insert plates with differentiated HEK 293 cells expressing MATE1 as well as the parental cell line. Drug-drug interactions involving MATE1 may result in decreased renal clearance and a corresponding increase in exposure, hence its importance when the development drug’s renal active secretion is significant.

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REFERENCE DESCRIPTION  
KRECE-HEK50 PreadyTake-CTRL (96 Multiwell)
KRECE-MAT50 PreadyTake-MATE1 (96 Multiwell)
KRECE-MAT51 PreadyTake-MATE1/CTRL 1:1 (96 Multiwell)

  Investigate the renal clearance of drug substrates

96 multiwell insert plates with differentiated HEK 293 cells expressing OCT2 as well as the parental cell line. The SLC (solute carrier) family transport a wide range of different solutes across biological membranes using diverse energy coupling mechanisms; OCT2 becomes critical when the development drug’s renal active secretion is significant.

More info...
REFERENCE DESCRIPTION
KRECE-HEK50 PreadyTake-CTRL (96 Multiwell)
KRECE-OCT50 PreadyTake-OCT2 (96 Multiwell)
KRECE-OCT51 PreadyTake-OCT2/CTRL 1:1 (96 Multiwell)

ReadyCell ready-to-use cell monolayer kits benefits

 

  • No in-house cell culture maintenance nor cell licensing costs
  • Shipments worldwide to any location at room temperature thanks to our patented technology
  • High flexibility
  • High reproducibility within and between manufacturing batches
  • Cell-based assays ready-to-use
  • Full cell functionality after transportation
  • Highly predictive and useful in the in vitro to in vivo progression
  • Validation data available and high quality-control standards
  • Technical support during the assay and in bio-analytics