CacoGlobel

A MUCUS SECRETING READY-TO-USE CONCEPT FOR IN VITRO INTESTINAL ABSORPTION EVALUATION

CacoGoblet, a mucus-secreting ready-to-use kit. The kit consists of 24 permeable supports seeded with differentiated polarized Caco-2 and human goblet cells.

CacoGoblet, allows in vitro intestinal absorption evaluation of drug targets in a barrier physiologically closer to the intestinal epithlium.

CacoGoblet is flexible, since plates can be used up to 5 days after ideal cell barrier differentation at day 21, being a time and cost-saving tool for early stage drug discovery and development.

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BENEFITS

  • Mucus secreting CacoGoblet represents a more predictive model for compounds or formulations with passive diffusion transport pathway.
  • CacoGoblet allows end-users to avoid in-house maintenance and handling of cell cultures, thus reducing operating cost.
  • The kit has been designed to provide a user-friendly and suitable tool for High Throughput automated procedures.
  • CacoGoblet provides a 21-day barrier.
  • Out exclusive shipping medium ensures the stability of barrier properties.
  • High flexibility as the kit useable up to 5 days after 21-day cell barrier differentation.
  • Shipping medium is easy to remove by liquefaction at 37ºC.

 

 

 

 

FEATURES

  • Cell-based.
  • Ready-to-use.
  • 24 and 96-HTS insert–integrated plate format.
  • Exclusive solid shipping medium.

APPLICATIONS

  • Evaluation of oral absorption efficiency, oral bioavailability and oral toxicity.
  • Adaptation to High Throughput Screening of target compounds.
  • Study of mechanisms involved in oral and intestinal absorption
  • Suitable for research on new delivery systems.

CLINICAL IMPORTANCE

  • Goblet cells comprise the second major cell type of the intestinal epithelium.
  • HT29 goblet cells and Caco-2 absorptive cells can be grown as co-cultures with barrier properties and create tight junctions between Caco-2 and HT29.
  • Co-culture model for intestinal drug absorption and transport studies.

 

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