Permeability assays are important for understanding how molecules cross biological barriers, assessing both their ability to cross and the mechanisms involved. While drugs are often absorbed by passive diffusion, some molecules can also be substrates for membrane proteins or transporters.
The permeability assay protocol for Caco-2 cells serves as a cornerstone in understanding and predicting the intestinal absorption of pharmaceutical agents.
This research, titled Fragment-Based Discovery of a Series of Allosteric-Binding Site Modulators of β‑Glucocerebrosidase, highlights the potential of fragment-based drug discovery (FBDD) and employs permeability assays with CacoReady and PreadyPort plates.
The final presentation highlighted the potential of gut-on-a-chip technology to advance bioavailability and efficacy testing in the meat industry.
The event united all the participating companies and partners, who presented the 2023 achievements and the challenges they faced to the project manager. Each presentation showcased the remarkable progress and collaboration, underscoring our shared dedication to innovation and problem-solving.
The team presented the results of their study, in which they used CacoGoblet, a 21-day differentiated co-culture of human colon carcinoma cell lines (Caco-2 and HT-29), to screen the gastrointestinal anti-inflammatory properties of compounds.
