On May 15-17, the 22nd Barrier- and Transporter- days took place in Germany. At the event, Jonatan Cucala, R&D researcher at ReadyCell, presented a poster entitled “PreadyTake, an in vitro ready-to-use cell-based model to evaluate potential drug-transporter interactions.”
OATP1B1 and OATP1B3 are two influx transporters of the SLCO gene family that are primarily expressed in the sinusoidal membrane of hepatocytes.
Understanding the role of these transporters in the clearance of new molecular entities (NME) is normally performed in-vitro at the early stages of drug development.
Drug Drug interaction studies in preclinical stage, reduces unexpected adverse events rate in clinical trails
Specialized manufacturer of in vitro kits to evaluate uptake transporters, OCT2 and MATE1.
Specialized manufacturer of in vitro kits indicated to evaluate pharmacological relevant efflux and uptake receptors for TDI assays.
In vitro systems based on HEK293 cells are a recommended technique to assess MATE1 transporter interactions during preclinical stages.