Promising results for a new treatment against drug-resistant tuberculosis
The article highlights the discovery of a series of azetidine derivatives, known as BGAz compounds, that exhibit potent bactericidal activity against both drug-sensitive Mycobacterium tuberculosis and multidrug-resistant TB strains.
New Insights into drug formulation with ready-to-use Caco-2 cells
In a recent study published in the Future Pharmacology Journal, researchers from prestigious French companies examined the impact of four polyols on the permeability of seven active pharmaceutical ingredients (APIs).
A new study that uses CacoReady reveals a potent inhibitor for prostate cancer
Evaluating in vitro permeability with CacoReady plates was central to the study design. By quantifying the permeability of the synthesized compounds within Caco-2 cells, researchers could identify and select which compounds were best in terms of cellular adsorption.
Select the right well system for your research: A comprehensive guide.
In preclinical research, the choice of the appropriate well system format – whether it’s a transwell, non-transwell, or individual transwell – can significantly impact the outcome of experiments. Selecting the correct plate is crucial to working with permeability, toxicity, drug screening, or other assays.
Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?
MDCKII cells based in vitro system is a recommended model to evaluate blood-brain barrier permeability during CNS action novel compounds.