Promising results for a new treatment against drug-resistant tuberculosis
The article highlights the discovery of a series of azetidine derivatives, known as BGAz compounds, that exhibit potent bactericidal activity against both drug-sensitive Mycobacterium tuberculosis and multidrug-resistant TB strains.
New Insights into drug formulation with ready-to-use Caco-2 cells
In a recent study published in the Future Pharmacology Journal, researchers from prestigious French companies examined the impact of four polyols on the permeability of seven active pharmaceutical ingredients (APIs).
3DLIVER: Celebrating one year of progress in the project for advanced drug toxicity testing and discovery
The main aim of the 3DLIVER project is the generation of innovative human liver-derived 3D in vitro models as innovative ready-to-use kits for drug testing models, using human liver cells and extracellular matrix (ECM), to generate more reliable in vitro drug testing devices.
A new study that uses CacoReady reveals a potent inhibitor for prostate cancer
Evaluating in vitro permeability with CacoReady plates was central to the study design. By quantifying the permeability of the synthesized compounds within Caco-2 cells, researchers could identify and select which compounds were best in terms of cellular adsorption.
Select the right well system for your research: A comprehensive guide.
In preclinical research, the choice of the appropriate well system format – whether it’s a transwell, non-transwell, or individual transwell – can significantly impact the outcome of experiments. Selecting the correct plate is crucial to working with permeability, toxicity, drug screening, or other assays.