The article highlights the discovery of a series of azetidine derivatives, known as BGAz compounds, that exhibit potent bactericidal activity against both drug-sensitive Mycobacterium tuberculosis and multidrug-resistant TB strains.
In a recent study published in the Future Pharmacology Journal, researchers from prestigious French companies examined the impact of four polyols on the permeability of seven active pharmaceutical ingredients (APIs).
3DLIVER: Celebrating one year of progress in the project for advanced drug toxicity testing and discovery
The main aim of the 3DLIVER project is the generation of innovative human liver-derived 3D in vitro models as innovative ready-to-use kits for drug testing models, using human liver cells and extracellular matrix (ECM), to generate more reliable in vitro drug testing devices.
Evaluating in vitro permeability with CacoReady plates was central to the study design. By quantifying the permeability of the synthesized compounds within Caco-2 cells, researchers could identify and select which compounds were best in terms of cellular adsorption.
In preclinical research, the choice of the appropriate well system format – whether it’s a transwell, non-transwell, or individual transwell – can significantly impact the outcome of experiments. Selecting the correct plate is crucial to working with permeability, toxicity, drug screening, or other assays.
This innovative biotechnology is available to transport living cells at room temperature.