The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.
Specialized manufacturer of in vitro kits indicated to evaluate pharmacological relevant efflux and uptake receptors for TDI assays.
PreadyPort BCRP is a in vitro system based on transfected MDCKII cells overexpressing the BCRP transporter.
ReadyCell provides ready-to-use in vitro system for assessing the pharmacological role of the P-gp receptor in preclinical stages.
Caco-2 cells are considered a reference cellular model for basic research and drug discovery projects. ReadyCell supplies systems worldwide.