The evaluation of drug interactions in preclinical stages optimizes novel drug development
Drug-drug interactions (DDI) are an important risk factor for polymedicated patients, as they can compromise safety and alter the efficacy of medical treatments. These interactions are usually related to drugs, however, they have also been identified between...
Caco-2 Permeability Assay Protocol
Culturing Caco-2 cells in Transwell plates is considered the reference in vitro technique to evaluate intestinal permeability in novel orally administered compounds, according to leading regulatory agencies (FDA, EMA and PMDA). The primary outcome of such technique is...