Why evaluate MDR1 receptor affinity in CNS pharmacokinetic assays?
MDCKII cells based in vitro system is a recommended model to evaluate blood-brain barrier permeability during CNS action novel compounds.
Cytotoxicity Assay Protocol
Explore our comprehensive cytotoxicity assay protocol featuring advanced testing methods with CacoReady kits. Learn about TEER, LY flux, and how to predict drug toxicity effectively.
StretchBio holds its 18-month meeting
Our representatives participated in the 18-month meeting of the StretchBio project, held in Freiburg. The meeting was focused on the design and operation of the functional prototype of the sensor.
Toxicological evaluation of chemicals and the implications of human P-gp and BCRP transporters
Publications have confirmed the importance of developing safe chemical agents using membrane transporter analysis as a criterion. This is reflected in the field of pesticides, one of the areas in which this analysis has been most widely applied.
3DLIVER: Innovative Human-Derived 3D Liver Models for Drug Toxicity Testing and Discovery
The main objective of this project is to develop novel 3D in vitro tools derived from the human liver, relevant to the discovery and preclinical phases of drug development.
