The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.
The study detected the most powerful antioxidant and anti-inflammatory compounds among the investigated Citrus flavanones, and that the particular structural features of these molecules make them available at the intestinal level, where they can exert their remarkable anti-inflammatory activities.
Cell-based in vitro models are suitable to evaluate human phisiology optimizing research. This review introduce reference models to evaluate gastrointestinal metabolism.
Our collaborators Carla Sapienza and Marta Ollé are attending Farmaforum Madrid to discuss last updates in pharmaceutical and cosmetics research.
Specialized manufacturer of in vitro kits to evaluate uptake transporters, OCT2 and MATE1.
