It is well known that food intake changes luminal conditions in the stomach and the small intestine, modifying drugs bioavailability. Food-drug interactions are one of the major challenges for oral-administered drugs, even more so if considering the growing use of food supplements and functional foods.
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.
Cell-based in vitro models are suitable to evaluate human phisiology optimizing research. This review introduce reference models to evaluate gastrointestinal metabolism.
Caco-2 cells are considered a reference cellular model for basic research and drug discovery projects. ReadyCell supplies systems worldwide.
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