Last month, the ICH launched a draft on Drug Interaction Studies regulatory. The guideline includes the regulations of the European, American and Japanese medical agencies and covers both in vitro and clinical studies.
The cell-based in vitro kits are shipped to South America, ensuring the quality standards. The patented biotechnology Shipping Medium® and the specialized logistic procedure at room temperature, achieve the proper delivery despite the long distances. ReadyCell is constantly growing and reaching out to more and more countries around the world.
The endothelial cells that conform the BBB limit the passage of blood circulating endogenous substrates and larger molecules to the brain. This intrinsic protective role is also a major hurdle for reasearchers developing drugs for Central Nervous System (CNS) disorders.
The study detected the most powerful antioxidant and anti-inflammatory compounds among the investigated Citrus flavanones, and that the particular structural features of these molecules make them available at the intestinal level, where they can exert their remarkable anti-inflammatory activities.
Cell-based in vitro models are suitable to evaluate human phisiology optimizing research. This review introduce reference models to evaluate gastrointestinal metabolism.
Transmembrane efflux receptors, Pgp, MRP1 and BCRP has shown a relevant effect in the chemoterapy resistance.
